Bursky Fellows 

The Shan lab is broadly interested in host immune response to HIV infection. Novel mouse models that contain multiple human gene knock-ins can improve support human hematopoiesis and maturation and survival of human immune cells in the mouse system. Using the novel humanized mouse models, the Shan lab will study virus-specific human T cell and NK cell responses in controlling HIV-1 infection and clearing viral reservoirs. With the state-of-the-art IML Core Lab at the Bursky Center for Human Immunology, the Shan lab will particularly focus on the antigen-specificity of HIV-specific T cells in order to understand the viral evolution under immune pressure and how to develop vaccine strategies to eradicate HIV infection.